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Insect ID Montreal, Qc Canada


I found this bug in my kitchen, in front of my oven. It has wings and moves quite slowly on the ground.

I can provide additional pictures if required.

Can somebody tell me what it is?

I have found an article on a local website that seems to say this is a carpet beetle even though it's written bedbug right bellow it.

http://www.exterminationmontrealbedbugs.com/insects/


Dermestidae, Reesa vespulae; wasp nest dermestid http://pestcontrolcanada.com/5965-2/


I agree that it appears to be a Dermestid of some kind, but I'm not a beetle pro, and so I'm not going to weigh in on the specific ID. Sometimes family is good enough, in my experience. I merely want to say that in my experience, commercial pest control websites are not places I would look to for accurate identification information. I'm sure they try hard, and some of them may have people on staff who know their business, but all too many simply cut and paste posters and photos from other locations, without regard for accuracy. The common "Spider ID" poster that pops up in the US, which features Australian species, is a frequent source of irritation for me.


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Transcriptomes of an oceanic diatom reveal the initial and final stages of acclimation to copper deficiency

Copper (Cu) concentration is greatly reduced in the open sea so that phytoplankton must adjust their uptake systems and acclimate to sustain growth. Acclimation to low Cu involves changes to the photosynthetic apparatus and specific biochemical reactions that use Cu, but little is known how Cu affects cellular metabolic networks. Here we report results of whole transcriptome analysis of a plastocyanin-containing diatom, Thalassiosira oceanica 1005, during its initial stages of acclimation and after long-term adaptation in Cu-deficient seawater. Gene expression profiles, used to identify Cu-regulated metabolic pathways, show downregulation of anabolic and energy-yielding reactions in Cu-limited cells. These include the light reactions of photosynthesis, carbon fixation, nitrogen assimilation and glycolysis. Reduction of these pathways is consistent with reduced growth requirements for C and N caused by slower rates of photosynthetic electron transport. Upregulation of oxidative stress defence systems persists in adapted cells, suggesting cellular damage by increased reactive oxygen species (ROS) occurs even after acclimation. Copper deficiency also alters fatty acid metabolism, possibly in response to an increase in lipid peroxidation and membrane damage driven by ROS. During the initial stages of Cu-limitation the majority of differentially regulated genes are associated with photosynthetic metabolism, highlighting the chloroplast as the primary target of low Cu availability. The results provide insights into the mechanisms of acclimation and adaptation of T. oceanica to Cu deficiency.

Appendix S1: Supplementary Information.

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Canadian science research centres

This list is not meant to be definitive or exhaustive. We welcome your suggestions of major Canadian research centres that can be added to this list. Please send ideas to [email protected]

Algonquin Wildlife Research Station

Long term wildlife research in the Ontario wilderness.

Annacis Research Centre, Metro Vancouver

Providing utilities, academia and private industry opportunities for wastewater research & technology development

Theoretical and fieldwork research.

Arctic Institute of North America

All aspects of research in North America's arctic regions including the natural and social sciences.

Avataq Cultural Institute

Mandate to identify, study, protect and preserve the archaeological heritage of Nunavik.

Vancouver, British Columbia

Basic and applied, avian research.

Azrieli Centre for Autism Research

Research, training and care for people with autism.

Bamfield Marine Sciences Centre

Bamfield, British Columbia

Coastal and marine research.

Biotron Institute for Experimental Climate Change Research Centre

Specialized environmental chambers.

Canadian Centre for Climate Modelling and Analysis

Develops computer models of the climate system to simulate global climate

Canadian Institute for Theoretical Astrophysics

Nationally supported research center for studies in theoretical astronomy and related subjects.

Canadian Institute for Advanced Research

Incubates ideas that revolutionize the international research community and change the lives of people all over the world.

Canadian Museum of Civilization

Established in 1856, Canada's centre for Archaeology and Ethnology research.

Canadian Museum of Nature

More than 10 million specimens gathered over more than 150 years.

Canadian Polar Commission

Yellowknife, North West Territories

Monitors, supports and promotes polar science to Canada and recommends polar science policy to government.

Focuses on the development of cleaner fossil fuels with a focus on oil sands and heavy oil .

Centre for Cold Ocean Resources Engineering (C-CORE)

Supports oil & gas development offshore Newfoundland & and other ice-prone regions with research in Remote Sensing, Ice Engineering and Geotechnical Engineering.

Center for Earth Observation Sciences

Monitors environmental changes.

Center for Earth Observation Sciences

Specializes in arctic science, monitors sea ice coverage.

Centre d'optique photonique et laser

Strategic cluster of optics/photonics researchers.

Centre for Intelligent Machines

Facilitates and promotes research on intelligent systems.

Centre for Mathematical Biology

Combines life scientists and mathematicians.

Centre for Particle Physics

Promotes interaction and collaboration among researchers in particle physics.

Centre interuniversitaire en calcul mathématique algébrique (CICMA)

Number theory and arithmetic geometry.

Applied engineering research and large-scale testing for the energy industry

Communications Research Centre Canada

Canadian federal government's primary laboratory for R&D in advanced telecommunications

Spacecraft assembly, integration and testing centre.

Dominion Radio Astrophysical Observatory

Penticton, British Columbia

Science and technology research related to radio astronomy.

Donnelly Centre for Cellular and Biomolecular Research

Multidisciplinary approaches to identify the causes and cures of diseases.

Mathematical research activity.

Freshwater Institute Science Laboratory

Regional Headquarters of Central and Arctic Region for Fisheries and Oceans Canada.

Global Aerospace Centre for Icing and Environmental Research Inc. (GLACIER)

Huntsman Marine Science Centre

Research and education in the marine sciences, including the Atlantic Reference Centre (ARC)&mdash a research museum for Canadian Atlantic marine life.

Institute for Space Imaging Science

Research areas include: Space plasma, auroral imaging, analysis and modeling.

Institute of Ocean Sciences

Fisheries and ocean research, environmental science and hydrography.

IREQ, Institut de recherche en électricité du Québec est reconnu comme étant le meilleur laboratoire au monde. Il y a des spécialistes reconnus mondialement dans le domaine de l'éolienne qui sont consultés par différents pays.

Shawinigan and Varennes, Quebec

Institute of Space and Atmospheric Studies

Solar terrestrial physics and planetary astronomy.

J.S. Marshall Radar Observatory

Atmospheric remote sensing.

Lyman Entomological Museum and Research Laboratory

Insect collection and systematic entomology laboratory.

McGill Arctic Research Stations

One of the longest-operating seasonal field research facilities in the high Arctic.

McGill University Herbarium

McMaster Ancient DNA Centre

Using DNA and protein in archaeological, paleontological, and forensic remains to answer biological questions.

National Research Council Research Centres

A listing of the dozens of NRC centres for scientific and engineering research

NRC Canadian Neutron Beam Centre

Uses neutron beams as probes to obtain new understandings of materials

Ontario Research Centre for Computer Algebra (ORCCA)

Fundamental research and development in mathematical software, focusing on computer algebra.

Transdisciplinary approach to research in origin-related topics using ideas and methods from a variety of subjects.

Pacific Institute for the Mathematical Sciences (PIMS)

Vancouver, British Columbia

Promotes excellent research and applications of the mathematical sciences.

Pacific Institute for Climate Solutions

Network of leading researchers from British Columbia and around the world to study climate change impacts and positive approaches to mitigation and adaptation.

Perimeter Institute for Theoretical Physics

Basic research centre dedicated to exploring the world around us at its most fundamental level.

Pipe Flow Technology Centre

International leader in practical pipeline applications.

Plasma Physics Laboratory

Research group specialized in magnetic fusion and plasma processing.

Proteomics Research Center

Studies of protein function and cellular networks with advanced and complimentary experimental approaches and technologies.

One of Canada's oldest free-standing museums, it preserves and displays large collections of ancient and modern organisms, minerals, and world culture (ethnological) artifacts.


Affiliations

Canadian Rivers Institute, Department of Biology, University of New Brunswick, P.O. Box 4400, Fredericton, NB, E3B 5A3, Canada

S. N. Andrews, B. Fleet-Pardy, T. Linnansaari & R. A. Curry

Inland Fisheries Division, Nova Scotia Department of Fisheries and Aquaculture, Pictou, Nova Scotia, Canada

Department of Biology, Acadia University, Wolfville, Nova Scotia, Canada

Faculty of Forestry and Environmental Management, University of New Brunswick, Fredericton, Canada


Abstract

TDP-43 nuclear depletion and concurrent cytoplasmic accumulation in vulnerable neurons is a hallmark feature of progressive neurodegenerative proteinopathies such as amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). Cellular stress signalling and stress granule dynamics are now recognized to play a role in ALS/FTD pathogenesis. Defective stress granule assembly is associated with increased cellular vulnerability and death. Ras-GAP SH3-domain-binding protein 1 (G3BP1) is a critical stress granule assembly factor. Here, we define that TDP-43 stabilizes G3BP1 transcripts via direct binding of a highly conserved cis regulatory element within the 3’UTR. Moreover, we show in vitro and in vivo that nuclear TDP-43 depletion is sufficient to reduce G3BP1 protein levels. Finally, we establish that G3BP1 transcripts are reduced in ALS/FTD patient neurons bearing TDP-43 cytoplasmic inclusions/nuclear depletion. Thus, our data suggest that, in ALS/FTD, there is a compromised stress granule response in disease-affected neurons due to impaired G3BP1 mRNA stability caused by TDP-43 nuclear depletion. These data implicate TDP-43 and G3BP1 loss of function as contributors to disease.


Ricardo Izquierdo

Panorama des différentes technologies permettant l'utilisation de l'hydrogène dans les Smart Grid (Power-to-Gas) et identification des points à améliorer pour réduire les coûts et améliorer l'efficacité, by Fourquin,Ulysse.
Winter 2021

Installation par hybridation des ressources énergétiques, by El Qotni,Nabil.
Summer 2020

Co-directed by: Kelouwani, Sousso
Chaîne de traction hydrogénique générique - cthg, by De La Cuesta,Ivan Benhur.
Summer 2020

Étude de faisabilité d'une installation de production d'hydrogène par électrolyse et photovoltaique, by Elbaz,Nathan.
Winter 2021

Alternatives électriques aux optimiseurs de puissance pour panneaux solaires, by Aldana Pachon,Juan Carlos.
Summer 2020

Étude sur l’intégration de panneaux photovoltaïques pour la création de résidences semi-autonomes, by Ferreira,Jason.
Winter 2020

Étude et simulation de cellules photovoltaïques à contacts arrière interdigités à opération concentrée, by Mghirbi,Safa.
Fall 2019

Systèmes de télémétrie pour le ski de fond, by Amghar,Walid.
Fall 2019

Comparaison de la performance de technologies photovaltaïques pour un micro-réseau autonome hybride à dix domiciles, by El-Rouby,Omar.
Summer 2019

Co-directed by: Lamarche, Louis
Dimensionnement des génératrices photovoltaïque et solaire thermique déployables, by Maneno Kichumu,Jean-Michel.
Fall 2020

Amélioration de l'économie des systèmes photovoltaïques pour des applications domestiques, by Ghane,Vajiheh.
Summer 2021

Co-directed by: Siaj, Mohamed
Évaluation du risque de la toxicité des nanoparticules MoSe2/Cu2Se sur l'algue aquatique unicellulaire Chlorella vulgaris, by Zaidi,Wassila.
Summer 2017

Études et modélisations des différentes technologies de cellules solaires sous influence de l'éclairement, by Rahmoune,Nawal Feriel.
Winter 2021

La réalisation et l'évaluation d'interconnexions entre cellules solaires pour la fabrication de modules photovoltaïques concentrée, by Khouider,Rosa.
Summer 2021

Dimensionnement de système solaire photovoltaïque pour une maison de campagne semi-autonome en conditions hivernales, by Mestiri,Ghazi.
Winter 2019

Identification d'un nouveau matériau pour électrode de cellule solaire photovoltaïque, by Rooryck,Cyrielle.
Summer 2019

Optimisation d'un système hybride photovoltaïque-éolien pour le dessalement de l'eau au village de pêche Sid El Ghazi au Maroc, by Amri,Fouad.
Summer 2019

Évaluation du rendement des panneaux solaires photovoltaïques concentrés en silicium monocristallin à contacts arrière, by Ore,Gbéniga Pierre.
Fall 2019

Stockage thermique saisonnier par puits géothermiques avec injection de chaleur, by Edhib,Randa.
Fall 2020

Conception d'une cafétéria à label NET Zéro sur une place publique de Montréal, by Brulant,Pauline.
Winter 2019

Co-directed by: Izquierdo, Ricardo
Identification de la source d'énergie renouvelable la plus adaptée à l'environnement et à l'acceptation sociétale, dans le cadre d'un projet de solidarité internationale, by Henry,Agathe.
Fall 2020

Étude de faisabilité d'un système autonome de production énergétique via les panneaux solaires photovoltaïques, by Njankou,Landry.
Winter 2021

Mise en marché d'un système de pile hydrogène pour véhicule de transport routier, by Gauthier,Patrick.
Fall 2021

Analyse comparative entre un système PV classique et PV direct pour combler les besoins en chauffage d'une maison conventionnelle au Québec, by Bonkoungou,Wend-Waoga Charles.
Summer 2021

Optimisation de modules photovoltaïques concentrés avec des cellules solaires en Si, by Alarcon Lujan,Karen Vanely.
Fall 2021

Co-directed by: Bourbonnais, Martin
Évaluation de l'utilisation de l'énergie photovoltaïque directe pour le chauffage et l'éclairage des serres agricoles, by Siala,Nourhene.
Summer 2021

Investigation on the Efficiency of Back-Contact Monocrystalline Silicon Solar Cells in Low Concentration and Non-Homogenous Illumination, by Sherafati,Ghazal.
Winter 2021

Sensor Fabrications and Implementation on Microsystems, by Ketabi,Mohsen.
Summer 2021

High Power Led-based Light Engine with Double Linear Fresnel Lenses for Solar Simulator, by Faghih,Ali.
Summer 2021

Electrochemical Printed PH Sensors in Food Packaging Systems, by Mahinnezhad,Shirin.
Summer 2021

Hydrogen Production Through Photovoltaic Energy, by Tayeban,Elnaz.
Summer 2021

Electrochemical Biosensors for Anaphylactic shocks, by Emami,Homa.
Summer 2021

Cellules solaires pérovkites imprimées et optimisation des couches pérovskites pour les cellules tandems, by Slimani,Moulay Ahmed.
Fall 2019

Utilisation des dispositifs MEMS pour la maintenance intelligente des machines industrielles, by Jemli,Mohamed.
Fall 2021

Fabrication par technique d'impression d'électrodes transparentes pour les cellules solaires pérovskites semi-transparentes et cellules tandem, by Palaco-Tobia,Daphne.
Fall 2021

Fabrication de couches minces de pérovskites sans plomb obtenues par dépôt physique pour des cellules solaires efficaces, stables et sécuritaires, by Ignoumba-Ignoumba,Ndembi.
Summer 2021

Crucial Electrical Components Combination and Optimization of a Photovoltaic Energy Harvesting System with Various Wind Power Equipment in Order to Increase Efficiency and Reduction of Installation Cost, by Daryaei,Amirhossein.
Fall 2021

Co-directed by: de Cambry, Jean
Étude d'un projet démonstrateur d'ilotage d'un bâtiment institutionnel alimenté par une installation photovoltaïque et éolienne, by Umurenzi,Celine.
Winter 2021

Co-directed by: Cambron, Philippe
Stockage d'énergie en lien avec l'intégration d'énergies renouvelables sur les réseaux de distribution, by Charon,Anaëlle.
Winter 2021

Co-directed by: Vayssieres, Samson
Maximisation de la production électrique d'une centrale de cogénération par l'ajout de panneaux photovoltaïques, by Vigeant,Stéphanie.
Fall 2021

Co-directed by: Zakaeia, Chayed
Analyse de l'échauffement de câbles souterrains dans un parc éolien on-shore et étude de la méthodologie de calcul d'ampacité, by Chaudret,Olivier.
Summer 2021

Co-directed by: Aimez, Vincent
Étude de l'influence de l'enneigement sur les capacités de production photovoltaïque, by Huguet,Sébastien.
Summer 2020

Co-directed by: Ollivier, Brendan
Dimensionnement de projets photovoltaïques pour des clients professionnels, by De Clerck,William.
Summer 2021

Co-directed by: Curvat, Laura
Étude de l'utilisation des containers maritimes pour le déploiement d'installations solaires photovoltaïques, by Alvy,Raphaël.
Winter 2021

Co-directed by: Soubdhan, Ted
Mise en place d'un plateau technique sur les bâtiments à énergie positive et énergies renouvelables, by Ramoutar Badal,Radji.
Winter 2021

Co-directed by: Izquierdo, Ricardo
Early Malaria Detection via Optical Fiber Sensing, by Azad,Saeed.
Fall 2021

Co-directed by: Cloutier, Sylvain G.
Procédés et matériaux à pérovskite pour l'électronique imprimé et hybride sur substrat flexible, by Slimani,Moulay Ahmed.
Fall 2021

Co-directed by: Cloutier, Sylvain G.
Devices and Structures Utilizing Aerosol Jet Printing: UV Photodetectors, Transmission Lines and Ring Resonators, by Gupta,Anubha A.
Summer 2019

Co-directed by: Izquierdo, Ricardo
Suspended Carbon Nanotube Beams Fabricated by a Low Temperature Surface Micromachined Process for Humidity and Gas Sensing, by Arunachalam,Shiva Ram.
Winter 2020

Co-directed by: Boulon, Loïc
Optimisation de la conversion d'un véhicule propulsé par un moteur à combustion interne vers une propulsion électrique utilisant des piles à combustible à l'hydrogène, by De La Cuesta,Ivan Benhur.
Fall 2021

Assistant directeur technique, by Njankou,Landry.
Winter 2021

Conception d'un procédé de fabrication d'électrodes flexibles transparentes, by Cornille,Vladimir.
Summer 2018

Deepak Thrithamarassery Gangadharan, Pandeng Li, Qingzhe Zhang, Fan Yang, Ricardo Izquierdo, Baoquan Sun, Dongling Ma. 2021. « Improving photovoltaic performance of Pb-Less halide perovskite solar cells by incorporating bulky phenylethylammonium cations ». Energy Technology. 11 p. (In press)

Deepak Thrithamarassery Gangadharan, David Valverde-Chavez, Andres-Felipe Castro-Mendez, Vivek Prakash, Ricardo Izquierdo, Carlos Silva, Dongling Ma, Juan-Pablo Correa-Baena. 2021. « Bulky cations improve band alignment and efficiency in Sn-Pb halide perovskite solar cells ». ACS Applied Energy Materials. vol. 4 , nº 3. 2616 p.

Shivaram Arunachalam, Ricardo Izquierdo, Frederic Nabki. 2020. « Ionization gas sensor using suspended carbon nanotube beams ». Sensors. vol. 20 , nº 6. 10 p.

Yuxuan Che, Yuliang Zhang, Yali Yang, Cheng-Hao Liu, Ricardo Izquierdo, Steven Shuyong Xiao, Dmitrii F. Perepichka. 2020. « Understanding the photovoltaic behavior of A-D-A molecular semiconductors through a permutation of end groups ». Journal of Organic Chemistry. vol. 85 , nº 1. p. 52-61.

Reda Elshafey, Patrick Brisebois, Haya Abdulkarim, Ricardo Izquierdo, Ana C. Tavares, Mohamed Siaj. 2020. « Effect of graphene oxide sheet size on the response of a label-free voltammetric immunosensor for cancer marker VEGF ». Electroanalysis. vol. 32 , nº 10. p. 2205-2212.

Anubha A. Gupta, Mohammad H. Rahmani, Michiel C. M. Soer, Sylvain G. Cloutier, Ricardo Izquierdo. 2020. « Aerosol jet printed, microwave microstrip ring resonators for system-in-package applications ». IEEE Transactions on Components, Packaging and Manufacturing Technology. vol. 10 , nº 11. p. 1913-1920.

Pandeng Li, Yuliang Zhang, Ting Yu, Qingzhe Zhang, Jean-Philippe Masse, Yingguo Yang, Ricardo Izquierdo, Baoquan Sun, Dongling Ma. 2020. « Unveiling photovoltaic performance enhancement mechanism of polymer solar cells via synergistic effect of binary solvent additives ». Solar RRL. vol. 4 , nº 10. 9 p.

Jeanne Ndiaye, Sujittra Poorahong, Ons Hmam, Gaston Contreras Jimenez, Ricardo Izquierdo, Mohamed Siaj. 2020. « Reduced graphene oxide-based foam as an endocrine disruptor adsorbent in aqueous solutions ». Membranes. vol. 10 , nº 11. 11 p.

Anubha A. Gupta, Michiel C. M. Soer, Mohammad Taherzadeh-Sani, Sylvain G. Cloutier, Ricardo Izquierdo. 2019. « Aerosol-jet printed transmission lines for microwave packaging applications ». IEEE Transactions on Components, Packaging and Manufacturing Technology. vol. 9 , nº 12. p. 2482-2489.

Pandeng Li, Mathieu Mainville, Yuliang Zhang, Mario Leclerc, Baoquan Sun, Ricardo Izquierdo, Dongling Ma. 2019. « Air-processed, stable organic solar cells with high power conversion efficiency of 7.41% ». Small. vol. 15 , nº 7.

Shivaram Arunachalam, Anubha A. Gupta, Ricardo Izquierdo, Frederic Nabki. 2018. « Suspended carbon nanotubes for humidity sensing ». Sensors. vol. 18 , nº 5. 11 p.

Anubha A. Gupta, Shivaram Arunachalam, Sylvain G. Cloutier, Ricardo Izquierdo. 2018. « Fully aerosol-jet printed, high-performance nanoporous ZnO ultraviolet photodetectors ». ACS Photonics. vol. 5 , nº 10. 7 p. p. 3923-3929.

Long Tan, Pandeng Li, Qingzhe Zhang, Ricardo Izquierdo, Mohamed Chaker, Dongling Ma. 2018. « Toward enhancing solar cell performance: An effective and "green" additive ». ACS Applied Materials and Interfaces. vol. 10 , nº 7. p. 6498-6504.

Deepak Thrithamarassery Gangadharan, Yujie Han, Ashish Dubey, Xinyu Gao, Baoquan Sun, Qiquan Qiao, Ricardo Izquierdo, Dongling Ma. 2018. « Aromatic alkylammonium spacer cations for efficient two-dimensional perovskite solar cells with enhanced moisture and thermal stability ». Solar RRL. vol. 2 , nº 4.

Deepak Thrithamarassery Gangadharan, Zhenhe Xu, Yanlong Liu, Ricardo Izquierdo, Dongling Ma. 2017. « Recent advancements in plasmon-enhanced promising third-generation solar cells ». Nanophotonics. vol. 6 , nº 1. p. 153-175.

Sujittra Poorahong, Ricardo Izquierdo, Mohamed Siaj. 2017. « An efficient porous molybdenum diselenide catalyst for electrochemical hydrogen generation ». Journal of Materials Chemistry A. vol. 5 , nº 39. p. 20993-21001.

Alireza Saidi, Laurent Desfontaines, Alain Champeval, Jean-David Lebreux, Christiane Lecomte, Michael Pruneau, Aurélie Grondein, Ricardo Izquierdo, Daniel Bélanger. 2017. « The effect of ink formulation and electrode geometry design on the electrochemical performance of a printed alkaline battery ». Flexible and Printed Electronics. vol. 2 , nº 1. 10 p. p. 15002.

Manon Sorais, Ali Rezaei, Joseph O. Okeme, Miriam L. Diamond, Ricardo Izquierdo, Jean-François Giroux, Jonathan Verreault. 2017. « A miniature bird-borne passive air sampler for monitoring halogenated flame retardants ». Science of the Total Environment. vol. 599-600 p. 1903-1911.

Long Tan, Fan Yang, Mee Rahn Kim, Pandeng Li, Deepak Thrithamarassery Gangadharan, Joëlle Margot, Ricardo Izquierdo, Mohamed Chaker, Dongling Ma. 2017. « Enhanced long-term and thermal stability of polymer solar cells in air at high humidity with the formation of unusual quantum dot networks ». ACS Applied Materials & Interfaces. vol. 9 , nº 31. p. 26257-26267.

Mee Rahn Kim, Hassan A. Hafez, Xin Chai, Lucas V. Besteiro, Long Tan, Tsuneyuki Ozaki, Alexander O. Govorov, Ricardo Izquierdo, Dongling Ma. 2016. « Covellite CuS nanocrystals: Realizing rapid microwave-assisted synthesis in air and unravelling the disappearance of their plasmon resonance after coupling with carbon nanotubes ». Nanoscale. vol. 8 , nº 26. p. 12946-12957.

Mamadou Diobet Diop, Moufid Radji, Anas A. Hamoui, Yves Blaquière, Ricardo Izquierdo. 2013. « Evaluation of anisotropic conductive films based on vertical fibers for post-CMOS wafer-level packaging ». IEEE Transactions on Components, Packaging and Manufacturing Technology. vol. 3 , nº 4. p. 581-591.

Ahmad Al Shboul, Ricardo Izquierdo. 2020. « Enhanced H2S sensing properties at room temperature of printed in 2O3-based sensors for food quality control applications ». 4th International Conference on Theoretical and Applied Nanoscience and Nanotechnology (TANNཐ) (En ligne, Nov. 09-11, 2020) International ASET Inc..

S. Arunachalam, F. Nabki, R. Izquierdo. 2019. « Suspended carbon nanotubes gas sensor ». Sensors and Electronic Instrumentation Advances : Proceedings of the 5th International Conference on Sensors and Electronic Instrumentation Advances (SEIA' 2019) (Canary Islands, Spain, Sept. 25-27, 2019) p. 297-298. IFSA Publishing.

Shivaram Arunachalam, Ricardo Izquierdo, Frederic Nabki. 2019. « Fabrication of an ionization gas sensor using suspended carbon nanotubes ». 18th IEEE Sensors (SENSORS) (Montreal, QC, Canada, Oct. 27-30, 2019) Institute of Electrical and Electronics Engineers Inc..

Saeed Azad, Satyendra K. Mishra, Manish Sharma, Ricardo Izquierdo, Bora Ung. 2019. « Low magnetic field detection via nanometre scale air-holes photonic crystal fiber filled with magnetic fluid ». 18th IEEE Sensors (SENSORS) (Montreal, QC, Canada, Oct. 27-30, 2019) Institute of Electrical and Electronics Engineers Inc..

Najet Belkhamssa, Mimoun Oukachmih, Mohamed Ksibi, Andy Shih, Ricardo Izquierdo. 2019. « Development of polyaniline-WO3-CuCl2 gas sensor on a flexible plastic substrate for humidity-insensitive detection of hydrogen sulfide gas ». 18th IEEE Sensors (SENSORS) (Montreal, QC, Canada, Oct. 27-30, 2019) Institute of Electrical and Electronics Engineers Inc..

Ahmad Al Shboul, Andy Shih, Mimoun Oukachmih, Ricardo Izquierdo. 2019. « Ppb sensing level hydrogen sulphide at room temperature using indium oxide gas sensors ». 18th IEEE Sensors (SENSORS) (Montreal, QC, Canada, Oct. 27-30, 2019) Institute of Electrical and Electronics Engineers Inc..

Philippe Descent, Ricardo Izquierdo. 2018. « Thermal transfer printing with donor ribbon for flexible hybrid RFID antenna fabrication ». 2018 International Flexible Electronics Technology Conference (IFETC) (Ottawa, ON, Canada, Aug. 07-09, 2018) Piscataway, NJ, USA : IEEE.

Philippe Descent, Ricardo Izquierdo, Christian Fayomi. 2018. « Printing of temperature and humidity sensors on flexible substrates for biomedical applications ». 2018 IEEE International Symposium on Circuits and Systems (ISCAS) (Florence, Italy, May 27-30, 2018) IEEE.

Ali Rezaei, Ricardo Izquierdo. 2018. « Rapid prototyping of microfluidic devices and their applications ». 16th IEEE International New Circuits and Systems Conference (NEWCAS) (Montreal, QC, Canada, June 24-27, 2018) p. 385-389. Institute of Electrical and Electronics Engineers Inc..

Yuliang Matthew Zhang, Ricardo Izquierdo, Shuyong Steven Xiao. 2018. « Printing of flexible, large-area organic photovoltaic cells ». 2018 International Flexible Electronics Technology Conference (IFETC) (Ottawa, ON, Canada, Aug. 7-9, 2018) Institute of Electrical and Electronics Engineers Inc..

F. S. Belaidi, A. Tsopela, L. Salvagnac, V. Ventalon, E. Bedel-Pereira, V. Bardinal, I. Seguy, P. Temple-Boyer, P. Juneau, R. Izquierdo, J. Launay. 2016. « Lab-on-chip with microalgal based biosensor for water assessment ». Nanotechnology Materials and Devices Conference (NMDC 2016) (Toulouse, France, Oct. 09-12, 2016) IEEE.

Anubha A. Gupta, Antoine Bolduc, Sylvain G. Cloutier, Ricardo Izquierdo. 2016. « Aerosol jet printing for printed electronics rapid prototyping ». 2016 IEEE International Symposium on Circuits and Systems (ISCAS) (Montréal, QC, Canada, May 22-25, 2016) p. 866-869. Piscataway, NJ, USA : IEEE.

Sujittra Poorahong, Florent Lefevre, Marie-Claude Perron, Philippe Juneau, Ricardo Izquierdo. 2016. « Integration of optical and electrochemical sensors on a microfluidic platform using organic optoelectronic components and silver nanowires ». Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBS) (Orlando, FL, USA, Aug. 16-20, 2016) p. 3002-3005. IEEE.

V. Ventalon, F. Sekli, R. Izquierdo, P. Juneau, A. Tsopela, J. Launay, V. Bardinal, P. Temple-Boyer, L. Salvagnac, I. Seguy, E. Bedel-Pereira. 2016. « Organic photodiode for detection of herbicides in water using microalgal photosynthesis ». Nanotechnology Materials and Devices Conference (NMDC 2016) (Toulouse, France, Oct. 09-12, 2016) IEEE.

Mamadou D. Diop, Moufid Radji, Walder Andre, Yves Blaquière, Anas A. Hamoui, Ricardo Izquierdo. 2010. « Electrical characterization of annular through silicon vias for a reconfigurable wafer-sized circuit board ». IEEE 19th Conference on Electrical Performance of Electronic Packaging and Systems (EPEPS) (Austin, TX, USA, Oct. 25-27, 2010) p. 245-248. IEEE Computer Society.

Anubha A. Gupta, Shivaram Arunachalam, Sylvain G. Cloutier, Ricardo Izquierdo. 2018. « Fully printed, ZnO photodetectors for ultraviolet sensing ». Communication during a conference : Photonics North 2018 ( Montreal, QC, Canada, June 05-07, 2018 )

Ricardo Izquierdo. 2018. « Printed sensors on flexible substrates for biomedical applications ». Communication during a conference : 40th Annual International Conference of the IEEE Engineering in Medicine and Biology Society ( Honolulu, HI, USA, July 17-21, 2018 )

Ricardo Izquierdo. 2018. « Toward green printing of organic solar cells ». Communication during a conference : EMP18 International Conference on Energy, Materials and Photonics ( Montreal, QC, Canada, July 08-11, 2018 )

Ricardo Izquierdo. 2017. « Combination of nanomaterials and organic semiconductors for electronic and optoelectronic device fabrication ». Communication during a conference : International Conference of Theoretical and Applied Nanoscience and Nanotechnology ( Toronto, ON, Canada, Aug. 24-28, 2017 )

Ricardo Izquierdo. 2017. « Highly stable low-dimensional perovskite solar cells processed from solutions at low temperature ». Communication during a conference : EMN Orlando Meeting 2017 ( Orlando, FL, Canada, Dec. 04-08, 2017 )

M. D. Diop, M. Radji, W. Andre, Y. Blaquière, A. A. Hamoui, R. Izquierdo. 2010. « Caractérisation électrique d'interconnexions avancées de type vias traversants (TSVs) pour une application à l'échelle d'un substrat ». Poster presented during a conference : 79e Congrès ACFAS/Colloque annuel ReSMiQ ( Sherbrooke, QC, Canada, Mai 2010 )


Insect ID Montreal, Qc Canada - Biology

Olivier Blarquez

My research mainly focuses on the interaction between natural disturbances and ecological processes at different spatial and temporal scales. I am particularly interested in long term response of Alpine, Boreal and Tropical ecosystems to fire disturbance, including biodiversity and ecosystem resilience aspects. I mainly study long-term ecological archives contained in natural sedimentary sites such as pollen, macroremains or charcoals to understand ecological processes and vegetation dynamics at millennia time scale.
Visiting scholar Julie Aleman email | website | ResearchGate Julie's research focuses primarily on understanding ecosystems dynamics and ecological processes at the landscape scale. She uses paleoecology and historical ecology to study past responses of vegetation structure to disturbances (especially fire), human impacts and climate change. She also uses a combination of remote sensing data and statistical modelling to study broad scale patterns of vegetation structure as a function of climate gradients, disturbance regimes and resource availability. Her main projects are towards understanding the drivers responsible for tree-grass coexistence in tropical savannahs , and for transitions between forest and savannah ecosystems. -->
Lab manager

Jordan Paillard
email

Jordan is currently lab technician working on several bioproxies and managing the lab. During his master’s thesis, Jordan studied the Holocene sugar maple migration in Abitibi-Témiscamingue and the influence of fire disturbance on this species. During his graduate and undergraduate studies, Jordan mastered the analysis of pollen and several other proxies commonly used in the lab such as charcoals and phytoliths . He is currently developing methods for image-based automated pollen and bioproxies analysis and counting.

Evrard Bi-Tchoko Kouadio (MSc 2015-, Dir. Yves Bergeron, UQAT)

Evrard obtained a master’s degree in botany and phytotherapy (option Phytochemistry) from the University of Abobo-Adjame (Ivory Coast) and a Master in Ecology, Biodiversity (option tropical plant biodiversity) from the University of Montpellier (France). He is particularly interested in the interactions between climate, fire disturbances and forest dynamics in boreal and tropical zones with the objective of identifying mechanisms which lead to environmental changes on a global scale. The aim of his thesis is to highlight the Holocene changes in vegetation between the spruce-moss (closed canopy forests) and spruce-lichen (open canopy) forests and the factors underlying this dynamic in mosaic landscapes from the northern Quebec.

Augustin Feussom Tcheumeleu (PhD 2017-, co-dir. Laurent Millet, UBFC)

Augustin a senior forestry technician, holder of a bachelor’s degree in sustainable forest management (Université de Lorraine, France), and a MSc in Biodiversity and ecosystems management ( AgroParisTech et Université de Montpellier, France ). He was trained in an interdisciplinary way in the context of tropical biodiversity, integrating biological knowledge and management issues. This covered various aspects of ecology, climate changes, relations between societies and ecosystems, conservation biology and management of ecosystems. He is interested in the answers that paleoecology provides to the main questions in ecology, particularly to the interactions between species, communities and climate over geologic time scale. Presently, he is studying Holocene climate changes, vegetation dynamics and fires in eastern Quebec . Augustin’s thesis relies on sporomorphs , charcoals and chironomids analysis of lake sediments, to characterize vegetation dynamics, to reconstruct paleofires and paleoclimates , and then assess the impact of climate change and other drivers on fire regimes.

Hugues Terreaux de Félice (PhD 2018-, Dir. Hubert Morin, UQAC)

Hugues obtained a master’s degree “Chrono-environnement et Paléoécologie ( CEPAGE )” from the University of Montpellier in France where he worked on carboniferous flora during the first year, and then moved in Québec at UQAC to work on insect outbreaks in a paleoecological setting for his second year. He is interested in paleo-environments and the identification of processes that modify the structure, nature and composition of ecosystems through geological time. Hugues thesis focuses on fire reconstruction and outbreaks of spruce budworm in the eastern boreal forest of Canada during the Holocene. The goal is to identify the nature of the relationship between fire and epidemics on different time scales. His results will provide a better understanding of the dynamics of natural disturbances in the boreal forest, as well as indications of the trends that these disturbances may have in the face of climate change.

Marc-Antoine Leclerc (PhD 2018-, Dir. Hubert Morin, UQAC)

Marc-Antoine obtained a Master of Science and a Bachelor’s in Sciences in Forest Sciences from the faculty of Forestry at the University of British Columbia. His Master’s thesis assessed the effects of mule deer winter range management on disturbances in the dry forests of central British Columbia. Marc-Antoine is particularly interested in biotic and abiotic disturbances, and their interactions at different spatiotemporal scales. Using a multi-proxy approach, his
current research project looks at reconstructing spruce budworm and wildfire events, and their interactions in the mixed boreal forest of central Québec over the past 10,000 years.

Simon Lebel Desrosiers (MSc 2017-, Dir. Nicolas Bélanger, UdeM)
email

Simon obtained his bachelor’s degree in environmental geography at the University of Montreal where he had the opportunity to work on the chemistry of soil solution samples collected from a small watershed called Hermine, situated at the Station de Biologie des Laurentides (SBL). For his thesis, he is studying the ecological factors that may affect the red oak’s (Quercus rubra L.) natural regeneration at the specie’s northern distribution boundary, which is of special interest in the context of climate change and possible assisted migration. His project is divided in two main chapters: 1) an experimental design that aims to test ash/charcoal fertilization treatments, predation and three different provenances plus the interaction of said factors in the early stages of regeneration dynamic (germination, early growth and survival) and 2) the reconstruction of the age structure of the two studied red oak stands at the SBL by systematic coring of trees in randomly selected plots, which should also yield insight into the type of natural perturbation occurring at the studied sites.

Médéric Durand (MSc 2020-)

Mes recherches portent sur les dynamiques holocènes des populations d’érables en dehors de leur aire de répartition. Plus particulièrement, je m’attarde sur les érablières à sucre se trouvant à la zone de transition des domaines de la sapinière à bouleau jaune et de la sapinière à bouleau blanc. De plus, je tente de comprendre les particularités des feux y permettant – ou pas – leur établissement dans de tels milieux. À ces fins, je fais principalement usage de données anthracologiques ainsi que polliniques en provenance de sédiments lacustres. De manière accessoire, le traitement de données dendrologiques fait aussi partie de mes recherches.

Andy Hennebelle (PhD 2016-2020, co-dir. Pierre Grondin, MFFP)

Andy obtained an engineer’s degree in Agronomy with a major in forestry and forest management from AgroParisTech Nancy.
During his studies, he has worked on the Spruce Budworm outbreaks and its consequences in the tree ring growth in Black Spruce and Balsam Fir forests in Québec. The second internship consisted in understanding how climate change will influence the phenology of 10 trees productive species in France.
His thesis focuses on the reconstruction of ecosystem processes in eastern Québec since the deglaciation by using pollen and charcoal records from lake sediments. His aim is to calibrate bioproxies taphonomy using recent sediment analysis, remote sensing and field surveys. He has a strong focus on understanding quantitatively vegetation, fire and climate dynamics. Those results will help to assess future projections and models for guiding forest management.

Charlène Mélançon (B.Sc. 2017- co.dir. Nicolas Bélanger)

Mes recherches s’intéressent à l’impact des perturbations naturelles que sont les feux de forêt sur la zone tempérée nordique du Québec. Plus précisément, je travaille sur de multiples sites affectés à différents niveaux par les derniers feux ayant eu lieu à la Station de biologie des Laurentides. Je tente de reconstituer le bilan carbone de ces zones et d’en déterminer les différences en termes de stocks, de flux et, par le fait même, de sensibilité à la température. L’utilisation de données de respiration des sols, de biomasse et de carbone contenu dans les sols est donc essentielle à mes recherches.

Jordan Paillard, 2018. Dynamique holocène de l’érable à sucre (Acer saccharum Marsh.) dans l’ouest du Québec. Mémoire de maîtrise en biologie, Université du Québec en Abitibi-Témiscamingue. 77 p.

Josianne Landry (Honor student, 2017) Influx pollinique et biomasse végétale Eeyou-Istchee – Baie-James

Jordan Fèvre (Master 2, EPHE, PARIS, 2011-2012)
Diversité herbacée et avalanche en forêt subalpine

Aurore Lucas (Master 2, University of Montpellier, 2010-2011)
Feu et dynamique de la biodiversité ligneuse dans la forêt boréale mixte canadienne de l’Ontario au cours de l’Holocène

Tasneem M. Elzein (Master 1 et 2, EPHE, Paris, 2008-2010).
Impact des avalanches de neige sur la structure, la composition et la dynamique des forêts subalpines

Thibault Frejaville (Master 1, University of Montpellier, 2008-2009).
Analyse paléoécologique des changements de diversité et de productivité


Major Discoveries

Schematic representation of the limited proteolysis of secretory precursor proteins

PCSK-generated cleavages can either activate the cognate precursor by releasing bioactive products or inactivate it by removing bioactive moieties. Substrates of proprotein convertases (PCs) are precursors of hormones, growth factors, receptors, transcription factors, surface glycoproteins, etc.

Schematic representation of the primary structures of the human proprotein convertases

The kexin-like basic amino acid (aa)-specific proprotein convertases, pyrolysin-like subtilisin kexin isozyme 1 (SKI 1 encoded by the MBTPS1 gene) and proteinase K like proprotein convertase subtilisin kexin 9 (PCSK9) are individually grouped to emphasize their distinct subclasses. The various domains and N glycosylation positions are emphasized, along with the primary (depicted using light grey arrows, and a light grey double arrow for SKI 1) as well as the secondary autocatalytic processing sites (depicted using dark grey arrows). Note that proprotein convertase 4 (PC4), PC7 and PCSK9 have only a primary site and that only PC5 exhibits two validated alternatively spliced forms, namely PC5A and PC5B. The membrane-bound human proprotein convertases include furin, PC4, PC5B, PC7 and SKI 1. The presence of a signal peptide, a prosegment and catalytic domain is common to all convertases that exhibit the typical catalytic triad residues Asp, His and Ser, as well as the Asn residue comprising the oxyanion hole (Asp for PC2). Downstream of the catalytic domain, all the basic amino acid-specific convertases, except for SKI 1 and PCSK9, exhibit a β barrel P domain that apparently stabilizes the catalytic pocket. The carboxy terminal domain of each convertase contains unique sequences regulating their cellular localization and trafficking. PC5 and paired basic amino acid cleaving enzyme 4 (PACE4) contain a specific Cys-rich domain, which binds to heparan sulphate proteoglycans at the cell surface and the extracellular matrix. By contrast, PCSK9 exhibits a Cys-His-rich domain (CHRD) that is required for the trafficking of the PCSK9–LDLR (low-density lipoprotein receptor) complex to endosomes and lysosomes.

Discovery of proprotein convertases (1990-2003). Nabil G. Seidah identified & cloned 7/9 members of the PC family. PC1, PC2 (DNA 1990 Mol Endo 1991) PC4 (Mol Endo 1992) PC5 (PNAS 1993) PC7 (PNAS 1996) SKI-1 (PNAS 1999) & PCSK9 (PNAS 2003). Furin (1990) & PACE4 (1991) were identified by Dutch and American groups, respectively. This was a truly enormous contribution in defining the molecular mechanisms underlying the cellular generation of active peptides/proteins from secretory precursors

PCs in the secretory pathway. Subcellular localization of proprotein convertases

Upon exiting the endoplasmic reticulum (ER), most of the basic amino acid-specific proprotein convertases traverse the Golgi apparatus towards the trans-Golgi network (TGN). At this branching point the proprotein convertase 1 (PC1) and PC2 are sorted to immature secretory granules where they are activated, cleave polypeptide hormones and are stored in dense-core secretory granules (SGs) awaiting signals for regulated secretion. Conversely, the constitutively secreted furin, PC5 and paired basic amino acid cleaving enzyme 4 (PACE4) reach the cell surface from the TGN. PC7 is able to reach the same destination from both the TGN and by an unconventional secretion pathway directly from the ER. Upon binding to heparan sulphate proteoglycans (HSPGs) and tissue inhibitors of metalloproteinases, PC5A and PACE4 are retained at the cell surface and/or extracellular matrix. The membrane-bound furin, PC5B and PC7 are recycled through endosomes back to the TGN. The activated membrane-bound subtilisin kexin isozyme 1 (SKI 1) is mostly concentrated in the cis- and medial-Golgi, from where it is then sent to lysosomes for degradation, and does not normally reach the cell surface. Proprotein convertase subtilisin kexin 9 (PCSK9) is secreted from the TGN directly into the medium as an enzymatically inactive non-covalent complex of the protease and its prosegment. Upon binding to the low-density lipoprotein receptor (LDLR) at the cell surface, the PCSK9–LDLR complex is internalized into endosomes and then sent to lysosomes for degradation.

Discovery of 7B2, the chaperone of PC2 (1982-present) and of β-endorphin & characterization of its precursor POMC (1976-1980)

The unexpected identification of 7B2 (FEBS Lett & Arch Biochem Biophys 1982/83), a 186 aa protein found in dense core granules of neural & endocrine cells, was made 13 years before the discovery of its major function, i.e., to chaperone the functional activity of PC2 (FEBS Lett 1995). Cloning of 7B2 mRNA & the KO of its gene revealed PC2-related functions (Biochem J 2001) & novel ones important in the regulation of aggressive behavior (JBC 2013). Exit of pro7B2 from the endoplasmic reticulum (ER) and its processing in the Trans Golgi Network (TGN) by furin to generate a C-terminal peptide (CT) that inhibits the activity of PC2. The CT-peptide is then inactivated by PC2 in immature secretory granules (ISG).

The seminal discovery of β-endorphin, its sequence & morphinomimetic activity (Lancet, 1976 Can J Biochem & BBRC 1976), & the processing of the precursors POMC & proInsulin were landmarks in peptide hormones & the generation of multiple functional peptides (ACTH, α,β,γ-MSHs, β-endorphin Insulin) via limited proteolysis at specific basic residues (PNAS 1978,1979 Int J Pept Protein Res 1984) & a harbinger for the future discovery of the cognate proteinases, the proprotein convertases (PCs).

Distribution of PC7 mRNA by Northern blot analysis in various cell lines and rat tissues

Autoradiograms show the expression of PC7 in brain regions, pituitary, digestive system, reproductive tissues, and various peripheral organs. Total RNA (5 mg) was loaded into each lane. The major form of PC7 observed is 4.2 kb. A band of lesser intensity is also sometime observed migrating at 6.5 kb. The rPC7 complementary RNA probe used was 285 bp containing nt 982–1266. The x-ray films were exposed for 3 days.

In situ hybridization histochemistry of PC7 mRNA distribution in the rat brain (A), pituitary (B), thymus (C), cerebellum (D), testis (E), and spleen (F). X-ray film exposures were for 4–7 days. The antisense 742-nt rPC7 complementary RNA probe represents nt 2170–2911. For controls, adjacent sections for each of these tissues were hybridized with the sense-strand PC7 probe of equal length and specific activity. No hybridization signal was observed in any of these controls (data not shown). Arc, arcuate nucleus of the hypothalamus DMH, dorsomedial hypothalamic nucleus VMH, ventromedial hypothalamic nucleus DG, dentate gyrus Hb, habenular nucleus AL, anterior lobe of the pituitary NL, neural lobe of the pituitary IL, intermediate lobe of the pituitary GL, granular layer of the cerebellum C, cortex of the thymus M, medulla of the thymus WP, white pulp of the spleen. A, 32.7 B, 36.5 C, 32.5 D, 33.0 E, 32.9 F, 32.5.

Autocatalytic processing of proPCSK9 and secretion of PCSK9-prosegment complex. Biosynthesis of PCSK9 in HK293 cells.

The V5-tagged PCSK9 or its active site mutant H226A were transiently expressed in HEK293 cells. The next day the cells were pulse-labeled with [35S]Met/Cys for 4 hours. Cell extracts (C) and media (M) were immunoprecipitated with a V5 antibody and the precipitates were & by SDS/PAGE on an 8% tricine gel. The migration positions of molecular mass standards (kDa), proPCSK9, PCSK9 and the prosegment are emphasized, together with the furin cleaved product observed. The active site mutant is neither cleaved not secreted, emphasizing the necessity of prodomain autocatalytic cleavage for PCSK9 to exit the ER and be secreted.

Schematic representation of proPCSK9 and schematic of the extracellular pathway of PCSK9-induced degradation of the LDLR

Schematic representation of proPCSK9 (75 kDa, 692 aa) and its processed form PCSK9 (62 kDa) that is non-covalently bound to the autocatalytically processed prodomain / (pro 15 kDa) at VFAQ152-SIP. Notice the active site residues Asp, His, and Ser and the oxyanion hole Asn, as well as the single N-glycosylation site (in blue).

High PCSK9 levels (left part of the graph) or GOF forms enhance the degradation of the LDLR following the endocytosis of the PCSK9–LDLR complex in clathrin-coated vesicles, together with the LDL, leading to the degradation of the PCSK9–LDLR complex in lysosomes. This results in low levels of the LDLR at the cell surface and increased levels of circulating LDL-c. Low levels of PCSK9 or LOF forms lead to increased levels of cell surface LDLR because the latter can be recycled back to the surface after delivery of LDL particles to acidic endosomes/lysosomes. PCSK9 mAbs target the extracellular pathway by sequestering extracellular PCSK9 and hence preventing its binding to the LDLR.

Inhibition of the PCSK9-induced LDLR degradation

Primary hepatocytes isolated from PCSK9 12-week-old male knockout mice were incubated with

5 μg/ml of human purified PCSK9 for 5 h at 37 °C in the absence (top ) or presence (bottom) of 0.35 μM evolocumab, a PCSK9 mAb inhibitor. After the first 3 h of incubation, 5 μg/ml of the fluorescent DiI-LDL (red) was added to measure LDL internalization for the next 2 hours. After the 5 hours of incubation, the cells were fixed for analyses. The level of cell-surface LDLR (green) was measured by immunocytochemistry with an anti-mouse LDLR antibody. Nuclei are stained with DAPI (blue). Notice the increase in cell-surface LDLR immunolabeling (green) and DiI-LDL internalization (red) in the presence of the mAb. Scale bar, 25 μm.

Proprotein convertases in health and diseases

The clinical fields relevant to each PC are indicated. To date, only PCSK9 is clinically targeted using mAbs. These mAbs are used for the treatment of hypercholesterolemia and are very promising for the prevention of septic shock. In this schematic, overlaps between PC clinical fields are only qualitative. Diabetes is related to both PC1/3 and PC2 through insulin processing. Cancers are mainly regulated by furin, PC5/6, and PACE4 (prostate) via processing of growth factors and their receptors. Most viral surface glycoproteins are processed by furin and, in some cases, by SKI-1/S1P (arenaviruses). Cholesterol and TG synthesis are regulated by SKI-1/S1P and LDL-c uptake by PCSK9. The convertase PC4 has a unique role in fertility, and PC7 in iron metabolism and anxiety/depression. Finally, in humans, PC1/3, PC5/6, and PACE4 were genetically linked to obesity, developmental defects, and osteoarthritis pain, respectively.



Prof. Mathieu Blanchette (Lab. Head)

After completing his Ph.D. (U. of Washington, 2002) and postdoc (UC Santa Cruz, 2003), Mathieu joined the School of Computer Science at McGill and founded the Computational Genomics Lab. The research made by his awesome team has been published in more than 70 publications. Recently elected member of the College of Scholar of the Canadian Royal Society, he was a Sloan Fellow (2009), and received the Outstanding Young Computer Scientist Researcher Prize from the Canadian Association for Computer Science (2012), and the Chris Overton prize (2006). He loves teaching and supervising students, and received the Leo Yaffe prize for teaching (2008).

Douglas Hoen (Postdoc)

Doug works on multiple aspects of transposable element identification, studies their domestication, and leads our TE benchmarking effort.

Glenn Hickey (Postdoc)

Glenn leads PIATEA, our project to annotate transposable elements using a multivariate Hidden Markov Model.

Adrian Platts (Bioinformatician)

Adrian works on a multitude of projects related to plant genome assembly, annotation, and comparisons.

Christopher Cameron (Ph.D. student)

Chris is a machine learning expert working on the analysis of 5C and Hi-C data, aiming to maximize the resolution and accuracy that can be obtained from these data. Co-supervised by Josee Dostie.

Pablo Cingolani (Ph.D. student)

Pablo develops computational approaches to facilitate genome-wide association studies and maximize its power in the presence of epistasis. Co-supervised by Rob Sladek.

Rola Dali (Ph.D student)

Rola is a molecular biologist by training who recently completed a transition toward bioinformatics. She studies gene expression in brain cancer, as well as chromosomal organization within the nucleus from Hi-C data.

Mickael Leclercq (Ph.D. student)

Mickael is our micro-RNA expert. He develops machine learning approaches to identify them and their targets, and studies their expression and evolution. Co-supervised by Aboudlaye Banire Diallo.

Airin Ahia-Tabibi (Ph.D. student)

Airin digs through ancient genomes to find traces of extinct transposable elements and

Faizy Ahsan (M.Sc. student)

Faizy develops cutting-edge machine learning approaches to predict and understand enhancer cell-type specificity. Co-supervised by Doina Precup.

Maia Kaplan (M.Sc. student)

Maia combines her computational and wet lab skills to study the function of domesticated transposable elements. Co-supervised by Thomas Bureau.

Willie Chang (Ugrad student)

Willy develops an approach to infer chromatin contacts from ChIP-seq data.


Watch the video: Playing with GIANT BUGS and a TARANTULA?? (December 2021).